Showing posts with label genetics. Show all posts
Showing posts with label genetics. Show all posts

Thursday, July 28, 2011

Prize for screening out mass killers

Legal weapons were used at Jokela and Kauhajoki school shootings and Oslo attack. The shooters had to get gun license first. The permitting process provides a checkpoint for screening out potential mass killers. Currently no effective screening exists to separate mass killers from the responsible and sane; therefore a prize is neeeded to give psychologists, criminologists and medical professionals incentives to create a test to screen out mass killers.

The prize would be based on pessimistic assumptions:
  • There are going to be more mass killings. Ways to prevent mass killings are not known.
  • Special brain function is needed for the monstrous lack of empathy which enables mass killings without war trauma, or delusionality where the murderer thinks he is an action hero tasked with saving the world by killing masses of nameless goons.
  • This brain damage may show up in hormone levels, genes regulating brain function, etc.
  • Shooting back is an effective way to stop an ongoing mass killing, for example Hyvinkää shooting stopped after the police returned fire. Effective screening paves the way for responsible and sane armed population. Should mass killers move to illegal guns (most regular gun kills are already done with illegal guns in Finland) then damage control through concealed carry permits is the only effective measure.
Genetic information already improves estimates about propensity to violence. The Finnish permitting process already screens out 2/3 of the criminals who would kill.

Update: The author of the linked article got his statistics wrong. He compares people with gun license killing with guns they own against kills by people without gun license using all methods. Gun kills are just a fraction of all kills, so it is an apples-to-oranges comparison.

Rules for the screening tests:
  • The tests can be based on any set of physiological measures like blood sample, genetic profile, saliva, urine, body height, etc.
  • The tests consist of a scoring algorithm for calculating pass/fail and a list of physiological measurements.
  • The tests can announce false positive for at most 10% of the population.

How prize money would be distributed:
  • After a mass killer is caught alive or dead, available physiological measures are taken. This enourages tests, which can be performed on the dead like blood samples, genetic profiles etc.
  • After each killing incident, 20% of the prize money is given for the tests which were positive for the killer. 80% remains in the fund for future killings.
  • The number of false positives is inversely proportional to the prize money. For example, a test flagging 0.01% of the population earns 100 times more than a test flagging 1% of the population.
  • Because of moral hazard, any research team with any links to the killer can't get prize money.
Here is an example of prize money division. Suppose that after a mass killing incident, two tests flag the killer. One of them flags 1% of the whole population, while another flags 0.01%. The price pot is 100000€, so 20000€ is awarded. The test flagging 0.01% of population earns 19802€, while the test flagging 1% of population earns 198€.

The institute administering the test would have to be international to get adequate sample size. It would also publish all physiological measures about the mass killers, and preferably also from other violent criminals and some voluntary controls without criminal record.

Without trying arrangements like this prize, we'll never know if modern psychology can screen out potential mass killers. What can be lost by trying?

Wednesday, October 06, 2010

MAOA and reconvictions


Helsinki University recommends that the decision to free a murder or keep him in jail should use genetic information among other data. If this is implemented, it is the first time that personality estimates based on genetic tests determine a person's future.

When a man is convicted to life in prison in Finland, he can only be released by pardon. Estimates about his danger to society are used when deciding about pardon. The existing method is to use PCL-R scale to estimate how psychopathic the person is. The steak of the new research is that MAOA gene + PCL-R score together provide even better estimate.

MAOA gene comes in high-activity and low-activity variants. Among convicts with low-activity MAOA, there is no link between PCL-R score are reconviction rate. Among high-activity MAOA convicts, each extra point in PCL-R increases reconviction rate with about 7%.

In many studies MAOA has been linked to depression and psychopathy, but the results are full of "ifs" at best and mutually contradictory at worst. If a person with low-acticity MAOA is exposed to childhood violence, it increases the risk of becoming a psycho. Links between MAOA and depression are contradictory. Individual studies have linked MAOA to economic risk taking and voting: People with high-activity MAOA prefer to take risk and use their vote, while low-activity MAOA carriers prefer to take insurance and vote less often.

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Should I start graduate studies next year, I should prepare for it already this year. The first step is to find a research topic. Bioinformatics seems like a good source of research topics. There are new results and new types of data coming out every year, so it should be possible to make solid research by merely applying standard computing science methods to some new problem. In this kind of applied research, the strong programming routine from industry background should be an advantage. This way I could avoid the need to catch up with 30 years of algorithm development history, a burden which handicaps for example state machine or graph theory research. Instead of developing those algorithms, my task would be to pick and combine algorithms and adjust them to the problem at hand. It is not easier, but it is more skill oriented and less memory oriented. Another advantage of applied bioinformatics research is that it has concrete goals to strive at. This does much to avoid buzzword-heavy, bullshitty basic research from which you can see straight away that it is never going to produce anything useful, which makes it extremely demoralizing for people working on it.

Tuesday, June 29, 2010

The difference between social democrats and transhumanists

Genetic testing tells some people that they have a high risk of disease. They can prepare for it if they hear about the illness years before its onsalught.

FuturePundit predicted in 2007 what actions people will take when genetic tests reveal information about their future:

But which risks will be worth testing for? Those you'll be able to do something about. Suppose a genetic variation makes Alzheimer's inevitable at middle age and that diet has little influence on when you'll get it. Well, I guess you could decide to avoid taking on family responsibilities that you won't be around to fulfill. But initially the biggest potential for doing something about a risk will involve risks that can be influenced by diet or exercise.

...

What you should do when you discover 5 or 10 years hence that you have high genetic risk of a disease: Write your elected officials and argue for more research on the disease you are on course to get. Lobby for cures for diseases that will otherwise kill you and your loved ones.

This is exactly what Sergey Brin did when he discovered by genetic testing that he has a hereditary risk for Parkinson's disease.

The article also contains a description of social democratic attitude, where people are considered helpless victims rather than players who execute moves to improve their position in the go board of life:

In the study, a team of researchers led by Robert Green, a neurologist and geneticist at Boston University, contacted adults who had a parent with Alzheimer’s and asked them to be tested for a variation in a gene known as ApoE. Depending on the variation, an ApoE mutation can increase a person’s risk for Alzheimer’s from three to 15 times the average. One hundred sixty-two adults agreed; 53 were told they had the mutation.

The results were delivered to the participants with great care: A genetic counselor walked each individual through the data, and all the subjects had follow-up appointments with the counselor. Therapists were also on call. “People were predicting catastrophic reactions,” Green recalls. “Depression, suicide, quitting their jobs, abandoning their families. They were anticipating the worst.”